Proteolytically activated anti-bacterial hydrogel microspheres
نویسندگان
چکیده
منابع مشابه
Proteolytically activated anti-bacterial hydrogel microspheres.
Hydrogels are finding increased clinical utility as advances continue to exploit their favorable material properties. Hydrogels can be adapted for many applications, including surface coatings and drug delivery. Anti-infectious surfaces and delivery systems that actively destroy invading organisms are alternative ways to exploit the favorable material properties offered by hydrogels. Sterilizat...
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Tyrosinase (o-diphenol: 02-oxidoreductase; EC 1.10.3.1) is present in the epidermis of Rana pipiens pipiens as an inactive proenzyme that can be activated by a variety of endopeptidases, chymotrypsin being the most effective. This proenzyme has been purified to homogeneity as judged by polyacrylamide gel electrophoresis. Inactive and active tyrosinase both have molecular weights of 200,000 =t 1...
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Clostridium septicum alpha-toxin is secreted as an inactive 46,450-Da protoxin. The protoxin is activated by proteolytic cleavage near the C terminus, which eventually causes the release of a 45-amino-acid fragment. Proteoytic activation and loss of the propeptide allow alpha-toxin to oligomerize and form pores on the plasma membrane, which results in colloidal-osmotic lysis. Activation may be ...
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UNLABELLED The optical response of porous silicon (pSi) films, covered with a quasi-hexagonal array of hydrogel microspheres, to immersion in ethanol/water mixtures was investigated. For this study, pSi monolayers were fabricated by electrochemical etching, stabilized by thermal oxidation, and decorated with hydrogel microspheres using spin coating. Reflectance spectra of pSi samples with and w...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2013
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2013.06.023